Dr Vijay Nambiar (Suresh Gopi) is a famous neurosurgeon. His wife Dr Nalini Nambiar (Abhirami) is a gynecologist in the same hospital. They lead a contented and busy family life. 'Appothikkiri' plots the intriguing issues that affect their life.

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Suresh Gopi

Jayasurya

Asif Ali

Abhirami

Meera Nandan